Odborný program přednášky


Monday  29 August 2022

16.00 - 19.00 Registration
19.00 - 20.30 Welcome cocktail - Campus

Tuesday 30 August 2022

08.00 - 17.00 Registration start + poster installation
10.00 - 10.30
Opening ceremony
  Chair: Kamil Kuča
10.30 - 11.15
Plenary lecture
  Chair: Ondřej Soukup
  Organotypic and microphysiological human tissue models for translational toxicology and pharmacology
Volker Lauschke (Stockholm, SWE)
11.15 - 11.40
Flash posters I
  Chair: Kamil Kuča

Absence of Multidrug Resistance-Associated Protein 2 Increases the Plasma Concentrations of Bile Acids in Rats with Estrogen-Induced Cholestasis
Fatemeh Alaei Faradonbeh (Hradec Králové, CZE)
Differences in the biological effects of bacterial and syntetic melanin
Jiří Handl (Pardubice, CZE)

Human Precision-cut Intestinal Slices as a Model to Study Drug-mediated Induction of Intestinal ABCB1 and CYP3A4
Martin Huličiak (Hradec Králové, CZE)

Disruption of the aryl hydrocarbon receptor (AhR) signaling alters functions and production of surfactant in a human model of alveolar type II cells
Martina Karasová (Brno, CZE)
Toxicity testing of new potential anthelmintics in parasitic nematode Haemonchus contortus and ovine liver
Linh Thuy Nguyen (Hradec Králové, CZE)
11.40 - 13.00 Lunch and Exhibition
13.00 - 14.05
Session 1 - Nanotoxicology
  Chairs: Tomáš Roušar, Daniel Jun
13.00 - 13.45
keynote lecture
One-dimensional nanomaterials and their (non)toxicity
Jan Macák (Pardubice, CZE)
13.45 - 14.05
Challenges in studying nanotoxicity in vitro
Tomáš Roušar (Pardubice, CZE)
14.05 - 14.30 Coffee break
14.30 - 16.10
Session 2 - Xenobiotics
  Chairs: Mojmír Mach, Ondřej Soukup
14.30 - 14.50
The role of UDP-glycosyltransferases in xenobiotic-resistance
Petra Matoušková (Hradec Králové, CZE)
14.50 - 15.10
Targeting tacrine hepatotoxicity associated with the CYP biotransformation
Ondřej Soukup (Hradec Králové, CZE)
15.10 - 15.30
Gene regulation of major CYPs via xenobiotic nuclear receptors
Petr Pávek (Hradec Králové, CZE)
15.30 - 15.50
Phenothiazine-Tacrine Heterodimers: Pursuing Multitarget Directed Approach in Alzheimer’s Disease
Jan Korábečný (Hradec Králové, CZE)
15.50 - 16.10
The effect of potential carcinogen harman on selected Cytochrome P450 enzymes in rats
Eva Klásková (Brno, CZE)
16.10 - 17.30
Posters with coffee and tea
18.30 - 21.30 BBQ evening - Campus

Wednesday 31 August 2022

08.30 - 09.15
Plenary lecture
  Chair: Jan Korábečný
  A paradigm shift in understanding the mechanisms of anthracycline cardiotoxicity and opportunities for effective pharmacological cardioprotection
Martin Štěrba (Hradec Králové, CZE)
09.15 - 10.40
Session 3 - In vitro Toxicology
  Chairs: Helena Kandárová, Kamil Kuča
09.15 - 10.00
keynote lecture
International TraiN-SafeMD project: collaboration towards improved safety assessment of medical devices
Helena Kanďárová (Bratislava, SVK)
10.00 - 10.20
3R strategies in reproductive toxicology and biomedicine
Iva Sovadinová (Brno, CZE)
10.20 - 10.40
Manganese(III) porphyrins as anti- and pro-oxidants in high-molar-mass hyaluronan oxidative degradation
Katarína Valachová (Bratislava, SVK)
10.40 - 11.10 Coffee break
11.10 - 13.00
Session 4 - Nutrition and Evinronmental Toxicology
  Chairs: Jan Vondráček, Jan Korábečný
11.10 - 11.40
keynote lecture
Natural phenolic compounds and biological trace metals: double-edged sword
Přemysl Mladěnka (Hradec Králové, CZE)
11.40 - 12.00
Uncoventional environmental toxic ligands of the aryl hydrocarbon receptor (AhR)
Jan Vondráček (Brno, CZE)
12.00 - 12.20
Towards the high-throughput assessment of thyroid hormone system disruptors
Ondřej Brózman (Brno, CZE)
12.20 - 12.40
Selected and serious below-limit sources of chemical risk in the Czech Republic
Otakar Jiří Mika (Praha, CZE)
12.40 - 13.00
Behavioral outcomes of maternal stress and perinatal mirtazapine treatment in rat offspring
Kristína Csatlósová (Bratislava, SVK)
13.00 - 14.00 Lunch and Exhibition
14.00 - 14.20
Flash posters II
  Chair: Kamil Musílek
Pharmacological modulation of m-TOR in animal model of NAFLD/NASH
Mahak Arora (Praha, CZE)
Cell growth on TiO2 nanotubes and ti flat substrates coated with metal oxides using atomic layer deposition
Jana Báčová (Pardubice, CZE)
Novichok: basic knowledge of biochemical properties
Vendula Hepnarová (Hradec Králové, CZE)

In vitro evaluation of BODIPY labeled bisquaternary amonium salts used as reactivators of inhibited acetlycholinesterase
Eliška Prchalová (Hradec Králové, CZE)
In vitro model expressing acetylcholinesterase for evaluation of neurotoxicity and neuroprotection
Lenka Pulkrábková (Hradec Králové, CZE)
14.20 - 15.50
Session 5 - Toxins and Military Toxicology I
  Chairs: Kamil Musílek, Michal Dubovický
14.20 - 14.50
keynote lecture
Nerve agent inhibited cholinesterases can be efficiently reactivated by oximes with enhanced nucleophilicity
Kamil Musílek (Hradec Králové, CZE)
14.50 - 15.10
Oxidative status assessment of rats‘ brain injury following subacute exposure to K-oximes
Vesna Jaćević (Belgrade, SRB)
15.10 - 15.30
Antidepressants in treatment of maternal depression: risks and benefits
Michal Dubovický (Bratislava, SVK)
15.30 - 15.50

Comparison of topoisomerase 2 inhibitors dexrazoxane and XK469 for the prevention of anthracycline cardiotoxicity
Anna Jirkovská (Hradec Králové, CZE)
15.50 - 16.30
Posters with coffee and tea
16.30 - 18.20 Tourist programme, Start: in front of the Campus building
19.00 - 00.00 Gala dinner, Hotel U Královny Elišky, Malé náměstí 117, Hradec Králové

Thursday 1 September 2022

08.30 - 10.30
Session 6 - Military Toxicology II
  Chairs: Jiří Kassa, Tanos Celmar Costa Franca
08.30 - 08.50

Memantine and its combination with acetylcholinesterase inhibitors in pharmacological pretreatment of soman poisoning in mice
Jiří Kassa (Hradec Králové, CZE)
08.50 - 09.10

Theoretical assessment of the performances of commercial oximes on the reactivation of acetylcholinesterase inhibited by the nerve agent A-242
Tanos Celmar Costa Franca (Rio de Janeiro, BRA)
09.10 - 09.30
Reactivation of acetylcholinesterase inhibited by novichok agents – a computational study
Tomáš Kučera (Hradec Králové, CZE)
09.30 - 09.50

Benchmark dose approach in evaluation of in vivo AChE-reactivating efficacy of promising experimental oximes K203 and K027
Evica Antonijevic Miljakovic (Hradec Králové, CZE)
09.50 - 10.10
In vitro decontamination efficacy of newly developed decontamination means on nerve agents
Alžběta Dlabková (Hradec Králové, CZE)
10.10 - 10.30
Chemical weapons from the perspective of international and national law
Otakar Jiří Mika (Praha, CZE)
10.30 - 10.50
Closing ceremony
  Kamil Kuča

The programme is subject to change.